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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRAP1 All Species: 18.79
Human Site: T220 Identified Species: 41.33
UniProt: P42345 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42345 NP_004949.1 2549 288892 T220 L R A C L I L T T Q R E P K E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535407 2550 288910 T220 L R A C L I L T T Q R E P K E
Cat Felis silvestris
Mouse Mus musculus Q9JLN9 2549 288718 T220 L R A C L I L T T Q R E P K E
Rat Rattus norvegicus P42346 2549 288776 T220 L R A C L I L T T Q R E P K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510680 2493 282092 C178 S S L P G G G C G M E L D E A
Chicken Gallus gallus XP_417614 2463 280042 T180 A E K G F D E T L A K E K G M
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001070679 2515 286136 T206 L R A C L I L T T Q R E T K E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VK45 2470 281015 A208 R A A L I V T A Q R E S T K Q
Honey Bee Apis mellifera XP_625130 2442 278856 R199 E G A V E A L R A A L V V T A
Nematode Worm Caenorhab. elegans Q95Q95 2697 306510 D261 A V R I A G I D A L H V V L T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32600 2474 281549 I247 R H A A L L I I K A L A D N S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 99.4 N.A. 98.9 98.9 N.A. 88.8 93.7 N.A. 89.8 N.A. 54 62 34.7 N.A.
Protein Similarity: 100 N.A. N.A. 99.5 N.A. 99.2 99.2 N.A. 91.2 95.4 N.A. 94.5 N.A. 69.8 75.7 53.4 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 0 13.3 N.A. 93.3 N.A. 13.3 13.3 0 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 6.6 20 N.A. 93.3 N.A. 40 13.3 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 40.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 58.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 10 73 10 10 10 0 10 19 28 0 10 0 0 19 % A
% Cys: 0 0 0 46 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 10 0 0 0 0 19 0 0 % D
% Glu: 10 10 0 0 10 0 10 0 0 0 19 55 0 10 46 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 10 10 19 10 0 10 0 0 0 0 10 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 0 10 10 46 19 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 10 0 0 0 0 0 10 0 10 0 10 55 0 % K
% Leu: 46 0 10 10 55 10 55 0 10 10 19 10 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 10 0 0 0 0 0 0 0 0 37 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 46 0 0 0 0 10 % Q
% Arg: 19 46 10 0 0 0 0 10 0 10 46 0 0 0 0 % R
% Ser: 10 10 0 0 0 0 0 0 0 0 0 10 0 0 10 % S
% Thr: 0 0 0 0 0 0 10 55 46 0 0 0 19 10 10 % T
% Val: 0 10 0 10 0 10 0 0 0 0 0 19 19 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _